Henoch-schoenlein Purpura: the Most Common Vasculitis in Children with Severe Renal Involvement
نویسنده
چکیده
Henoch-Schoenlein purpura (HSP) is a vasculitis of the small blood vessels with clinical presentation of a multi-organ involvement syndrome at variable expression in derma, intestine, articulations and kidney. Firstly identified by Heberden, Schoenlein described the purpuric and articular manifestations and Henoch the gastrointestinal and renal features. The combination of various systemic and renal symptoms leads to apparently different clinical entities and often overlaps the autoimmune diseases. The difficulty of correctly interpreting the frequent Henoch-Schoenlein purpura: The most common vasculitis in children with severe renal involvement
منابع مشابه
Henoch-Schönlein purpura.
Henoch-Schönlein purpura is an acute, systemic, immune complex-mediated, leukocytoclastic vasculitis. It is characterized by a triad of palpable purpura (without thrombocytopenia), abdominal pain, and arthritis. Most patients have an antecedent upper respiratory illness. More than 90 percent of Henoch-Schönlein purpura cases occur in children younger than 10 years; however, adults with this con...
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BACKGROUND Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. Severe central nervous system (CNS) involvement is rare in HSP. CASE CHARACTERISTICS Three children with features of HSP presented with seizures and CNS dysfunction. OBSERVATION All three children had abnormalities on neuroimaging; 2 had complete remission but one was left with severe neurological damage. ...
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Received: 18 Aug, 2008 Accepted: 14 Feb, 2009 Abstract Renal involvement is one of the most serious sequela of Henoch-Schönlein purpura. The presence of proteinuria (nephritic range) and hematuria is also associated with progression to renal insufficiency. In fifty percent of patients who display a combination of nephritis-nephrotic symptoms, end-stage disease develops. Pharmacologic treatme...
متن کاملRenal Involvement in Vasculitis
The renal involvement is common in any form of systemic vasculitis. These include classic polyarteritis nodosa, Wegener’s granulomatosis, microscopic polyarteritis, Churg-Strauss syndrome, and the hypersensitivity vasculitides (including Henoch-Schönlein purpura, mixed cryoglobulinemia, and serum sickness). Also vascultitis secondary to rheumatological disorders such as rheumatoid arthritis can...
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Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, while it is rare in adults. Typical clinical manifestations include palpable purpura without thrombocytopenia and/or coagulopathy, arthritis/arthralgia, abdominal pain, and/or renal involvement. In adulthood the disease tends to be more serious than in children, with renal manifestations developing over a period ...
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